![]() Here’s another example: the tier one blaze class increases magic aptitude by 10% while the tier two windrunner class decreases magic aptitude by 25%. When an acolyte turns into a paladin, you’ll see their speed aptitude drop by 30% back to the character’s original base. ![]() For example, the tier one acolyte class adjusts the character’s base speed aptitude by +30%, while the tier two paladin class doesn’t change speed aptitude at all. This may seem obvious for tier one, but for tier two this means that aptitude changes will look different depending on what tier one class you chose for a character. It is important to understand that in this guide, the aptitude adjustments you see should be applied to the character’s base aptitudes. Tier one classes and tier two classes both grant 2 new skills as well as adjusting the character’s aptitudes. Instead, each character has a personal skill that influences how they play. Base classes also don’t have skills except for the unique action that the class enables: shoving for warriors, healing for clerics, etc. However, when moving from tier one to tier two, it is possible to choose a tier two class that isn’t on the same row as the tier one class (and therefore thematically similar).īase classes don’t have their own aptitudes – instead, each character has their own personal aptitudes. There is no way to change to a different class once a promotion is chosen, nor is there a way to change into a different archetype entirely. There is then a second promotion into tier two classes at level 30. Each of these classes has four tier one classes they can promote into at level 10. There are six base classes in the game on which the other 48 are built: warrior, ranger, cleric, mage, rogue, and adept. Each section will start with the base class on which an entire archetype is built, then describe the tier one classes before moving on to the tier two classes. The purpose of this guide is to provide a useful reference to the details of each class. ![]() ![]() Classes affect the weapons and armor your characters wield, their aptitudes for each of the game’s stats, and the skills they pick up to improve their odds in battle. As you play through the game you get two major opportunities to choose what class you would like each character to occupy. Dark Deity features a total of 54 different classes across 6 broad archetypes. ![]()
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![]() Merck is investing in M&A activity to strengthen its pipeline. ![]() Merck boasts a strong cancer pipeline, including Keytruda, which should drive long-term growth. With continued label expansion into new indications & early-stage settings, Keytruda is expected to remain a key top-line driver.Īnimal health and vaccine products are core growth drivers. Company’s products like Keytruda and Gardasil have been driving sales. Merck’s shares have outperformed the Zacks Large Cap Pharmaceuticals industry over the past year (+33.7% vs. (You can read the full research report on UnitedHealth Group here >) As such, the stock warrants a cautious stance. High operating costs are hurting margins. However, the membership in its global business continues to decline. A sturdy balance sheet enables business investments and prudent deployment of capital. The Government business remains well-poised for growth. UnitedHealth Group’s solid health services segment provides diversification benefits. The company’s top line remains well-poised for growth on the back of a strong market position, new deals, renewed agreements and expansion of service offerings. Shares of UnitedHealth Group have gained +3.8% over the past year against the Zacks Medical - HMOs industry’s gain of +5.7%. You can see all of today’s research reports here > ![]() ![]() These research reports have been hand-picked from the roughly 70 reports published by our analyst team today. Today's Research Daily features new research reports on 16 major stocks, including UnitedHealth Group Inc. The Zacks Research Daily presents the best research output of our analyst team. Today's Must Read Solid Top Line & Strong Cash Flows Drive UnitedHealth (UNH) Keytruda to Remain Merck's (MRK) Key Top Line Driver Embedded Processing Strength Aids Texas Instruments (TXN) ![]() ![]() ![]() I have the software stated, but when I do "svn co kolmafia" it returns 'svn' is not recognized as a command. Drag and drop the "KoLmafia-x.x" folder onto Disk Utility. ![]() the major changes of this version: Use of Java 1.8 Use of a new XML format for Plugin Manager. Generate the application bundle inside of the "KoLmafia" folder created earlier jEdit is a programmers text editor written in Java.Also inside the "KoLmafia-x.x" folder, create a symbolic link to "/Applications".Inside the "KoLmafia-x.x" folder, create a "KoLmafia" folder.If you actually need the DMG for one reason or another: Add a key/value pair, with "app.name" being the key, and anything you want being the value.Make sure the Java runtime compatibility is 1.4+.Drag and drop the "limeglass.icns" file in the "lib" folder into the icon section.Select the KoLmafia.jar generated in a build.Load up JAR Bundler, located in "/Developer/Applications/Java Tools".If all you need is the application bundle: If you're having problems with that step, post here and I'll explain more in detail.ĮDIT: Edited address for Java and made it clicky -DaychildeĮdited to update to the correct url for svn, the previous one quit working. There's a guide at the ant website though. Note: Ant can be a bit tricky to install. Once it finishes, go to the subdirectory and type: Open command prompt ("cmd" for XP/2k users) and type: Next, find a directory where you want the builds to go. JDK 1.4 or later (1.5.0 is the latest) (, you can find it) If I made any mistakes, feel free to correct me.įirst, grab a copy of the following software: Anyway, for other aspiring devel noobs like myself, here's a quick intro on what to do running under WinXP/2k. Okay, I might be a total idiot here, but how would I go about downloading the latest KoLmafia code from the SVN and building it? I have the JDK and basic computer skills, although no java knowledge. ![]() ![]() Perhaps you’d like to do something completely different. Perhaps you’d like to pick a single card, any card, and make a game based on its specific themes and symbols. Perhaps you’d like to invent a brand new game using the Tarot (or the more “standard” deck of playing cards derived therefrom) as a primary component. Perhaps you want to create an alternative synchronistic divinatory system, like the Tarot or the I Ching. The challenge was to make a game that deliberately used glitches as an integral part of gameplay or that otherwise embraced a glitched-out aesthetic.įor the purposes of this jam, participating developers/artists are welcome to use the Tarot as a general theme, a structural guideline, a creative jumping off point, or simply a source of inspiration. Glitch Jam was an official Game Jolt jam. Seeing as this is cyberpunk, literally almost anything goes content wise. Heck Deck (Ludum Dare version) bullet hell card game torcado Play in browser Ripple Runner A Bit.trip Runner-style chiptune rhythm game. While that is more solarpunk than cyberpunk, it still fits within the parent genre. Create a game within the time allowed to leave a positive influence on the impending future using the theme and motives of the cyberpunk genre. I believe we should use it for positive ones, not negative. Pokemon Unbroken Bonds: Theme Deck - Lightning Loop. Cyberpunk JamĪs game developers, we have responsibilities to influence the future. by Daniel Linssen Support This Game The Sun And Moon By Daniel Linssen Made for Ludum Dare 29. – To show off projects that are pushing the boundaries of generative software. – To build a community of friends and peers across disciplines. – To host a jam that is laid back, easy to enter, and fun to be a part of. – To make procedural generation accessible to more people. #procjam is a game jam about making stuff that makes other stuff. Ludum Dareevents take place every April, August and December. During a Ludum Dare, developers from around the world spend a weekend creating games based on a theme suggested by the community. sakin added Heck Deck (Ludum Dare version), The Machine, Tiny Snek Heck, Arctic Fighters, Bearsus, Aztec Ride to games to play. Ludum Dare is an online community best known for“Ludum Dare”, the Accelerated Game Development Event of the same name (also called a “Game Jam”). The GGJ encourages people with all kinds of backgrounds to participate and contribute to this global spread of game development and creativity. It is all condensed into a 48 hour development cycle. The weekend stirs a global creative buzz in games, while at the same time exploring the process of development, be it programming, iterative design, narrative exploration or artistic expression. It is the growth of an idea that in today’s heavily connected world, we could come together, be creative, share experiences and express ourselves in a multitude of ways using video games – it is very universal. ![]() Think of it as a hackathon focused on game development. The Global Game Jam® (GGJ) is the world’s largest game jam event (game creation) taking place around the world at physical locations. ![]() ![]() ![]() ![]() As best I could tell, the idea was to just stand there and let the dogs do all the work while occasionally hitting the brakes to keep things from getting too nuts out there on the trail, but it's hard to say. Once outside, Cathérine began showing us the dogsledding basics on a sled that had no dogs attached to it. 14 books for those that love to laugh on your holiday gift list.22 works of nonfiction from around the world to watch for this fall.American comedian Dave Hill has Canadian roots - so he toured the country to learn about them.Hill is a comedian based in New York City. The result, he promises, is "the greatest Canada-based literary thrill ride of your lifetime." ( From Doubleday Canada) But now, inspired by a publisher's payment of several hundred dollars (Canadian) in cash, he has travelled all over the country, reconnecting with his heritage in such places as Montreal, Moose Jaw, Regina, Winnipeg, Merrickville and of course Clinton, Ontario, meeting a range of Canadians, touching things he probably shouldn't and having adventures too numerous and rich in detail to be done justice in this blurb. In later years he even visited Canada a couple of times. (That last part is a lie, but hopefully it makes the point that he was so into Canada that it was actually kind of weird.) And he was more vocal about the vast merits of the Canadian healthcare system than any nine-year-old you'd ever want to meet. Likewise, if a song by Triumph came on the radio, he'd be the first to ask for it to be cranked up as loud as it would go. Whenever bacon was served at home, he'd be sure to mention his preference for the Canadian variety. While his peers kept busy with football, basketball and baseball, hockey became the only sport for Dave. And every Sunday at dinner he'd remind Dave and anyone else within earshot that it was in fact Canada, this magical and mysterious land just across the mighty Lake Erie, that was the "best." His grandfather, you see, was from Canada (Clinton, Ontario, to be exact). The idea that their country is the "best." But this never stuck with Dave Hill, even though he was born and raised in Cleveland, Ohio. There's an idea most Americans tend to learn as children. ![]() ![]() ![]() Strawberries are mainly water and do not put on weight. It is amazing that five or six strawberries has the same filling the stomach effect as a slice of bread. My diet has changed and probably for the better. I hope so as I would not go on O****** again unless I simply *had* to. The question is can I maintain this low 90 Kgs weight. I weighed in at 104 Kg in October, last week at the doctors surgery I tipped the scales at 91 Kg. And then I felt confident enough to venture into town. I stuck with the medication for six months and it was another month before my body had returned to normal. I felt that I could go nowhere, not to the shops, no visiting. The diarrhea lasted for many weeks thus limiting my movement. It almost amounted to that on that night. As I use crutches to move around at night time, I thought that I would have to sleep on the throne. The diarrhea was so bad one night that I stopped counting after ten visits to the bathroom. This left me feeling drained, often for days on end. Not so, the nausea was replaced by diarrhea which was frequent and, for want of a better descriptive term, explosive. Some weeks went by without any side effects leading me to think I had weathered the storm. ![]() The side effects of O****** were, in my case, very extreme and difficult to live with. ![]() Very soon my trousers was many sizes too big for me, a bit like the pictures of extreme weight loss that 'shows' how effective such and such a diet is.īut, and there is a big but. My main problem foods were milk, bread and potatoes. I soon discovered that I had been eating way too much food for my needs and I started to lose weight. O****** works be suppressing your appetite, this it does in spades. My wonderful wife did the injecting, which to be honest, was almost painless and nothing to worry about. It comes in a pen that injects a measured dose about two mm into the skin. O****** is expensive, and it is not allowed to claim for it on the Drugs Refund Scheme. As my mobility is limited, he suggested that I use a product called O******* which he said would do that job if I could stick with it for six months. Actually he said I should lose two stone. Last October, a consultant that was referred to told me that it would be better if I lost some weight. ![]() ![]() ![]() How much does a gorilla weigh? How many pounds a does gorilla weigh?Īn adult male gorilla weighs between 300 and 430 pounds, while a female gorilla weighs between 150 and 250 pounds. An adult wild female gorilla weighs between 68 and 113 kg. An adult wild male gorilla weighs from 136 to 195 kg. Both species and even subspecies of guerrillas have different amounts of weight. Habitat also affects their weight, and they are generally heavier in captivity than in the wild. How much does a gorilla weigh?Īs gorillas have such sexual diaphragms, there are prominent differences in the weight and size of both sexes. You will find the average gorilla weight, both male and female gorilla weight, adult and baby gorilla weight and the largest gorilla weight in the world. We have collected complete information about gorilla weight so you can get a clear idea of how much gorilla weight you can do. ![]() Due to their large size, their weight is also sufficient. The gorillas are not only strong but also have a good-sized muscular body. When a full-grown female gorilla weighs 86 to 113 kg (150 to 250 pounds). What is the weight of a full-grown Silverback Gorilla?Ī full-grown male gorilla weighs 136 to 195 kg (300 to 430 lbs). The average silverback weighs about 350 pounds and stands five-and-a-half feet tall, striking a silverback 10 times out of a Grizzly 10. He could have a strip of hair on his back. The lowland gorillas are 4 to 6 feet (1.2 to 1.8 meters) tall and weigh 150 to 400 pounds … They found that he could turn on and off his intense odor … called silver, which was often marked by gray. 300-400 pounds is the weithgt of a healthy, mature male Silverback. To straighten the record, gorillas cannot weigh close to 800 pounds. The physical weight of the subspecies of the Mountain Gorilla Silverbacks (Gorilla berinzi berini) weighs 195 kg (430 lbs). Other sources say the average weight of the Silverback gorillas of the sub-species of eastern lowland gorillas (Gorilla berinzi grueri) is up to 160 kg (350 lbs). Gorillas’ arms are longer than their legs and their hands are about 30 cm (1 ft) tall. This article will be sharing facts about how much does a silverback gorilla weigh? How much does a silverback gorilla weigh?Īdult male mountain gorillas (Gorilla berengi berinzi) can weigh up to 220 kg (484 lbs) and wives. , However, adult females usually weigh about half as much as a male. How much does a silverback gorilla weigh? The gorillas are ground-dwelling, predominantly herbivorous apes that live in the center of the forest Human gene sequences differ only 1.6% on average compared to the sequence of gorilla genes, wild male gorillas weigh 136 to 195 kg (300) 430 lbs). ![]() ![]() ![]() You can! As long as the document is in one of Kindle’s accepted formats, simply email that document as an attachment to your Kindle. You may delete, sort, and manage away! Can I Email a Personal Document to Kindle? This should bring up a list of emailed content. ![]() Then, find the drop down menu that says books. If you need to manage your content, especially the content you’ve emailed to your Kindle, on your account, simply log into your Amazon account and navigate to Digital Content and Devices (instructions above). Your book should appear in your queue, and you can download it and start reading ASAP!
![]() ![]() Master Lost Sectors were also added, being even more difficult than their Legend variant in having additional modifiers and Champions. On completion, it awards them some Enhancement Cores and sometimes an Exotic Armor of a specific slot if it was completed solo. Defeating Champions gives the player an additional revive. Similar to their previous iteration, they had higher difficulty and modifiers, as well as having a limited amount of revives, similar to Grandmaster Nightfalls. They are accessed through a flag, similar to the ones used to enter adventures and campaign missions, but also rotate on a daily basis. Legendary Lost Sectors, now renamed to Legend Lost Sectors, returned in the Beyond Light expansion. Offering significantly higher difficulty than regular Lost Sectors, they featured modifiers and Champions, similar to Nightfalls. They were accessed through a console situated next to Rasputin's screens within each Seraph Bunker once that bunker was cleared for the day. Legendary Lost Sectors were an activity available during Season of the Worthy.
![]() ![]() Thus, cytidine, for example, refers to a nucleoside (no phosphate), but cytidine monophosphate refers to a nucleotide (with one phosphate). The number of phosphates in the nucleotide is indicated by the appropriate prefixes (mono, di or tri). Nucleotides are often referred to as nucleoside phosphates, for this reason. The addition of one or more phosphates to a nucleoside makes it a nucleotide. Of these, deoxyuridine and ribothymidine are the least common. adenine-containing = adenosine (attached to ribose) / deoxyadenosine (attached to deoxyribose).guanine-containing = guanosine (attached to ribose) / deoxyguanosine (attached to deoxyribose).cytosine-containing = cytidine (attached to ribose - Figure 2.129) / deoxycytidine (attached to deoxyribose).thymine-containing = ribothymidine (attached to ribose) / thymidine (attached to deoxyribose).uracil-containing = uridine (attached to ribose) / deoxyuridine (attached to deoxyribose).When a base is attached to a sugar, the product, a nucleoside, gains a new name. Both DNA and RNA contain nucleotides with adenine, guanine, and cytosine, but with very minor exceptions, RNA contains uracil nucleotides, whereas DNA contains thymine nucleotides. Nucleotides containing ribose are called ribonucleotides and are found in RNA. Nucleotides containing deoxyribose are called deoxyribonucleotides and are the forms found in DNA. Figure 2.128 - Nucleotides, nucleosides, and bases (This is to distinguish the carbons on the sugars from those on the bases, which have their carbons simply labeled as 1, 2, 3, etc.) Deoxyribose differs from ribose at the 2’ position, with ribose having an OH group, where deoxyribose has H. By convention, the carbons on these sugars are labeled 1’ to 5’. There are two sugars found in nucleotides - deoxyribose and ribose (Figure 2.128). The nitrogenous bases found in nucleic acids include adenine and guanine (called purines) and cytosine, uracil, or thymine (called pyrimidines). ![]() ![]() Molecules that contain only a sugar and a nitrogenous base (no phosphate) are called nucleosides. These are a nitrogenous base, a pentose sugar, and at least one phosphate. Nucleotides contain three primary structural components. In order to discuss this important group of molecules, it is necessary to define some terms. The term nucleotide refers to the building blocks of both DNA (deoxyribonucleoside triphosphates, dNTPs) and RNA (ribonucleoside triphosphates, NTPs). Read in groups of three, the sequence of the bases directly specifies the sequence of the amino acids in the encoded protein. Crucially, the sequence of the bases in DNA carry the information for making proteins. In addition to the hydrogen bonds between bases of each strand, the double helix is held together by hydrophobic interactions of the stacked, non-polar bases. The complementary structure immediately suggested to Watson and Crick how DNA might be (and in fact, is) replicated and it further explains how information is DNA is transmitted to RNA for the synthesis of proteins. Figure 2.127 - A DNA duplex with base pairs, a closeup of base pairing, and a closeup of a nucleotide Wikipedia Two hydrogen bonds are formed between adenine and thymine, but three hydrogen bonds hold together guanine and cytosine (Figure 2.127). The double helix, made up of a pair of DNA strands, has at its core, bases joined by hydrogen bonds to form base pairs - adenine always paired with thymine, and guanine invariably paired with cytosine. Today, every high school biology student is familiar with the double helical structure of DNA and knows that G pairs with C and A with T. Arguably, that one-page paper has had more scientific impact per word than any other research article ever published. Their famous paper, in the Apissue of Nature, opened the modern era of molecular biology. X-ray diffraction work of Rosalind Franklin and the observations of Erwin Chargaff were combined by James Watson and Francis Crick to form a model of DNA that we are familiar with today. Discovered in 1869 by Friedrich Miescher, DNA was identified as the genetic material in experiments in the 1940s led by Oswald Avery, Colin MacLeod, and Maclyn McCarty. The race to elucidate the structure of DNA was one of the greatest stories of 20th century science. We will begin with DNA, which is the hereditary information in every cell, that is copied and passed on from generation to generation. In this section, we will examine the structures of DNA and RNA, and how these structures are related to the functions these molecules perform. The nucleic acids, DNA and RNA, may be thought of as the information molecules of the cell. The entire textbook is available for free from the authors at ![]() |